Insuline allergy

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averomania Posted: Wed, Aug 15 2012 6:57 PM

Case study:

My mother has been a (slim) T2 diabetic for the past 10 years. She is 78 years now. She started with a FBS of 200 mg/dL 10 years ago, then was treated with Medformin increasing dose from 1000 mg/day to 3000 mg/day. All this time her FBS was not going below 120 mg/dL (actually staying mainly in the 145 mg/dL). HbA1C in 2010 was 8.77. I must admit that even if my mother was keeping a diabetic diet, she would eat a cookie or even chocolate cake from time to time. She lost a lot of weight during these 10 years. From 132 lb in 2002 she ended with 115 in 2011. She looked like a mummy.

Last year after an unsuccessful 2 month trial with Januvia she was finally put on insulin. Started with 2 doses/day of Humalog and 6 months later switched to 18 units/day of Lantus. Her HbA1C decreased from 9.5 to 8.3. She also gained some weight (had 125 lb in Jan 2012).

After 3 months of Lantus my mother developed a local allergic reaction to Lantus. She was immediately switched to Levemir with the same reaction. Intradermal testing to 4 types of insulin analogues showed allergy to all of them. Her HbA1C jumped to 10.3.  

Now my mother is back on Medformin (2000/day) with a FBS of 200-220 mg.dl.  Her HbA1C is 11.12. Given the fact that she is living alone, using an insulin pump seemed not a feasible option.

 

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amrad replied on Wed, Aug 15 2012 10:52 PM

did they test on the animal based insulin?

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They tested: Humalog, Lantus, Levemir & Humulin R (I think).

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amrad replied on Thu, Aug 16 2012 8:33 PM

I wonder if they would consider trying the Hypurin Pork Insulin available in Canada, also available in the UK,  if in the US you would have to import it, but that is not a big deal just a form you have to fill out.

Unfortunately the big insulin companies stopped producing it because they could make more money with the analogue insulins. Some people have bad reactions to the newer insulin.

The iddt.org website has all the details.

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