Diabetic Nephropathy 17 Years, on Dialysis

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ckdsite Posted: Fri, Apr 6 2012 2:51 AM

Diabetic Nephropathy is a secondary kidney disorder which is caused by long time diabetes. Diabetes is a disease which can lead to damage to all capillaries in the system due to long time high blood glucose. Kidney is an organ which will be damaged as well.

Long time Diabetes without enough insulin and with high blood glucose and immune dysfunction leads to a series of pathological changes of glomerular intrinsic cells, which causes broadening of glomerular basilar membrane, narrowing of lumen. It results in the shrinking of blood vessel, which causes ischemia and anoxia of kidney, damage of capillaries surrounding glomerular and tubules and further inflammation infiltration. It starts the process of renal fibrosis. Kidney fibrosis refers to healthy kidney intrinsic cells are replaced by large quantity of extracellular matrix which can develop into glomerulosclerosis and tubular necrosis.

Diabetic Nephropathy 17 Years, on Dialysis

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